Toxicology 2027 | Toxicology and Applied Pharmacology | Creovate Conferences

PhD, Center for Translational Neuroimaging, Northeastern University, Boston, MA, USA

Affiliation: PhD, Center for Translational Neuroimaging, Northeastern University, Boston, MA, USA

Topic: Beyond the Dose–Response Curve: Contextual and Organ-System Toxicity of Psychedelics

Psychedelic compounds are approaching regulatory approval faster than their toxicology has been characterised. Two psilocybin programmes and one entactogen programme now hold accelerated review status in the United States; several state legislatures have appropriated public funds for ibogaine trials; and regulated non-clinical psilocybin services already operate in Oregon and Colorado. Within the timeframe of this conference, one or more of these compounds may be licensed medicines. The toxicology of this drug class does not reduce to a single dose–response relationship. It separates into two domains that obey different rules, and a scientific programme that addresses only one of them will mislead.

Dr. Mostafa Ould Elhkim is a regulatory toxicologist with nearly 40 years of experience in toxicology research, regulatory science, risk assessment, and public health. His career combines fundamental research in carcinogenesis and mutagenesis with extensive expertise in the scientific evaluation and regulation of medicinal products for human and veterinary use, chemicals in food and animal feed, as well as cosmetics, biocides, and plant protection products. He has held senior scientific and managerial positions respectively at the French Agency for Veterinary Medicinal Products (ANMV), the French Food Safety Agency (AFSSA), and the French National Agency for the Safety of Medicines and Health Products (ANSM). He has also contributed to scientific activities at the European level through collaborations with the European Medicines Agency (EMA), the European Commission, and international expert working groups. In parallel with his regulatory responsibilities, Dr. Ould Elhkim has served as a lecturer at the University of Paris-Est Créteil (UPEC), where he coordinates the teaching unit on Physico-Chemical Risk Assessment. He is the author of numerous scientific publications and currently serves as a peer reviewer for Food and Chemical Toxicology, having also reviewed manuscripts for several other international peer-reviewed journals. His expertise includes regulatory toxicology, pharmaceutical safety, chemical risk assessment, carcinogenesis, mutagenesis, environmental and occupational health, and evidence-based public health.